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Urinary Biomarkers for Bladder Outlet Obstruction

  • BPH-Related Voiding Dysfunction (R Lee, Section Editor)
  • Published:
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Abstract

Purpose of Review

Lower urinary tract symptoms (LUTS) in elderly men are often caused by bladder outlet obstruction (BOO) as a result of benign prostatic hyperplasia (BPH). The consequences of BOO-induced LUTS include the low compliance high pressure bladder as well as the high volume low pressure bladder with loss of bladder function.

Recent Findings

Timely diagnosis of BOO may help prevent bladder decompensation and preserve organ contractility. In this review, we will discuss the latest developments in the quest for reliable urinary biomarkers of BPH-induced benign prostatic obstruction (BPO). We will summarise the possible mechanisms of BOO-induced bladder remodelling and their implications for the diagnosis and therapy of BOO-induced LUTS.

Summary

A number potential of urinary biomarkers and non-invasive tests have been proposed for BOO, but do not seem to have enough specificity and sensitivity. Combinations of proteins, miRNAs and small molecules need to be evaluated to increase the reliability and discriminative potential of biomarkers.

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Authors and Affiliations

  1. Urology Research Laboratory, Department Clinical Research, University Hospital, University of Bern, Murtenstrasse 35, 3008, Bern, Switzerland

    Katia Monastyrskaya

  2. Department of Urology, Inselspital, Bern University Hospital, 3010, Bern, Switzerland

    Fiona C. Burkhard

Authors
  1. Katia Monastyrskaya
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  2. Fiona C. Burkhard
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Correspondence to Katia Monastyrskaya.

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Drs. Monastyrskaya and Burkhard declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on BPH-Related Voiding Dysfunction

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Monastyrskaya, K., Burkhard, F.C. Urinary Biomarkers for Bladder Outlet Obstruction. Curr Bladder Dysfunct Rep 12, 129–137 (2017). https://doi.org/10.1007/s11884-017-0418-3

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  • DOI: https://doi.org/10.1007/s11884-017-0418-3

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